Temperature dependence of optical properties of in-vivo human skin

Shu-Jen Yeh; Omar S. Khalil; Charles F. Hanna; Stan Kantor; Xiaomao Wu; Tzyy-Wen Jeng; Rene Alexander Bolt

doi:10.1117/12.434482

29 June 2001 Temperature dependence of optical properties of in-vivo human skin

Shu-Jen Yeh, Omar S. Khalil, Charles F. Hanna, Stan Kantor, Xiaomao Wu, Tzyy-Wen Jeng, Rene Alexander Bolt

Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434482
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

We examined the effect of temperature change on the diffuse reflectance of the skin. The optical probe consists of several optical fibers located at the center of a thermal electric device, which controls the temperature at the surface of the skin in contact. Measured light reflectance profile between 0.4-1.9 mm was fitted to a mathematical model obtained by Monte Carlo simulation, and absorption and scattering coefficients were estimated. The reduced scattering coefficient of the forearms consistently showed a positive relationship with temperature between 22 and 42 degree(s)C. This dependency was reversible without apparent delay. The same effect was observed on ex vivo pigskin. It is possible to explain the positive instantaneous dependency of scattering on temperature by the change of the refractive index of intercellular fluid. The scattering coefficient of the subcutaneous fat of pigskin showed a negative dependence on temperature. This negative dependency of scattering can be attributed to a phase change as a function of temperature. The absorption coefficient in vivo also increased with temperature from 22 to 42 degree(s)C. But the change was not immediately reversible after temperature reached 40 degree(s)C. This relationship was similar to the nonlinear increase in blood perfusion observed in laser Doppler measurements.

Citation Download Citation

Shu-Jen Yeh, Omar S. Khalil, Charles F. Hanna, Stan Kantor, Xiaomao Wu, Tzyy-Wen Jeng, and Rene Alexander Bolt "Temperature dependence of optical properties of in-vivo human skin", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434482

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