Photodynamic diagnostic in atherosclerotic artery wall of rabbits

Elaine Aparecida Corbani; Katia Calligaris Rodrigues; Raduan Hage; Janaina Duarte; Landulfo Silveira Jr.; Antonio G. J. Balbin Villaverde; Renato Amaro Zangaro; Marcos T. T. Pacheco

doi:10.1117/12.427832

21 May 2001 Photodynamic diagnostic in atherosclerotic artery wall of rabbits

Elaine Aparecida Corbani, Katia Calligaris Rodrigues, Raduan Hage, Janaina Duarte, Landulfo Silveira Jr., Antonio G. J. Balbin Villaverde, Renato Amaro Zangaro, Marcos T. T. Pacheco

Author Affiliations +

Proceedings Volume 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI; (2001) https://doi.org/10.1117/12.427832
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

A growing number of studies have demonstrated that autofluorescence and induced fluorescence spectroscopy can be used to distinguish normal and abnormal tissues in vivo. Through photochemical accumulation in atherosclerotic lesions it is possible to obtain induced fluorescence, this accumulation has been demonstrated in many researches. The aim of this study was to diagnose, by aluminum phthalocyanine transadventitial fluorescence, atherosclerotic plaques in artery wall of rabbits. Five male Norfolk rabbits were submitted to a high level cholesterol diet for 9 weeks. When the blood cholesterol level reached around 1000 mg/dl three of these animals were injected intravenously 50(M/50(l of aluminum phthalocyanine (AlPc). After 24 hours these animals were submitted to a surgery to expose the iliac artery. The transadventitial fluorescence spectra were acquired in several points over the artery. Characteristic peaks of the collagen, the porphyrin and the induced by AlPc were observed.

Citation Download Citation

Elaine Aparecida Corbani, Katia Calligaris Rodrigues, Raduan Hage, Janaina Duarte, Landulfo Silveira Jr., Antonio G. J. Balbin Villaverde, Renato Amaro Zangaro, and Marcos T. T. Pacheco "Photodynamic diagnostic in atherosclerotic artery wall of rabbits", Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); https://doi.org/10.1117/12.427832

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