Acne phototherapy using UV-free high-intensity narrow-band blue light: a three-center clinical study

Alan R. Shalita; Yoram Harth; Monica Elman; Michael Slatkine; Gerry Talpalariu; Yitzhak Rosenberg; Avner Korman; Arieh Klein

doi:10.1117/12.427830

21 May 2001 Acne phototherapy using UV-free high-intensity narrow-band blue light: a three-center clinical study

Alan R. Shalita, Yoram Harth, Monica Elman, Michael Slatkine, Gerry Talpalariu, Yitzhak Rosenberg, Avner Korman, Arieh Klein

Author Affiliations +

Proceedings Volume 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI; (2001) https://doi.org/10.1117/12.427830
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Propionibacterium. acnes is a Gram positive, microaerophilic bacterium which takes a part in the pathogenesis of inflammatory acne. P. acnes is capable to produce high amounts endogenic porphyrins with no need of any trigger molecules. Light in the violet-blue range (407-420 nm) has been shown to exhibit a phototoxic effect on Propionibacterium acnes when irradiated in vitro. The purpose of our study was to test the clinical effects of a high intensity narrowband blue light source on papulo pustular acne. A total of 35 patients in 3 centers were treated twice a week with a high intensity metal halide lamp illuminating the entire face (20x20 cm2) or the back with visible light in the 407-420 nm range at an intensity of 90 mW/cm² (CureLight Ltd.) for a total of 4 weeks. UV is totally cut off. In each treatment the patient was exposed to light for 8-15 minutes. After 8 treatments, 80% of the patients with mild to moderate papulo-pustular acne showed significant improvement at reducing the numbers of non- inflammatory, inflammatory and total facial lesions. Inflammatory lesion count decrease by a mean of 68%. No side effects to the treatment were noticed. In conclusion, full face or back illumination with the high intensity pure blue light we used exhibits a rapid significant decrease in acne lesions counts in 8 biweekly treatments.

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Alan R. Shalita, Yoram Harth, Monica Elman, Michael Slatkine, Gerry Talpalariu, Yitzhak Rosenberg, Avner Korman, and Arieh Klein "Acne phototherapy using UV-free high-intensity narrow-band blue light: a three-center clinical study", Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); https://doi.org/10.1117/12.427830

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