Clinical experiences with fluorescence guided resection of malignant glioma

Walter Stummer; Susanne Stocker; Herbert G. Stepp; Karl Bise; Hanns-Juergen Reulen; Reinhold Baumgartner

doi:10.1117/12.389472

28 June 2000 Clinical experiences with fluorescence guided resection of malignant glioma

Walter Stummer, Susanne Stocker, Herbert G. Stepp, Karl Bise, Hanns-Juergen Reulen, Reinhold Baumgartner

Proceedings Volume 4166, Laser Florence '99: A Window on the Laser Medicine World; (2000) https://doi.org/10.1117/12.389472
Event: Laser Florence '99, 1999, Florence, Italy

Abstract

Survival after surgery and radiotherapy of malignant glioma is closely linked to the completeness of tumor removal. Therefore methods are needed that permit intra-operative identification of tumor border lines. For tumor staining 5-ALA induced PPIX is used. The influence of fluorescence guided resection on the survival is analyzed. 66 patients received 20 mg/kg bodyweight 5-ALA per os 3 hours before anaesthesia. Fluorescence was visualized using a modified operating microscope. Fluorescing tissue was removed as complete as possible. 72 hours after surgery MIII —images were taken and residual enhancements quantified. Patients survival was analysed using the Kaplan-Meier method in correlation with Karnofsky-status, age, histology of tumor. These 66 patients were compared to 89 patients operated on between 1990 — 1992. Complete resection ofmalignant and fluorescing tumor was obtained in 62 % of patients. Compared to the historical group ofpatients survival using 5-ALA was significantly prolonged.

Citation Download Citation

Walter Stummer, Susanne Stocker, Herbert G. Stepp, Karl Bise, Hanns-Juergen Reulen, and Reinhold Baumgartner "Clinical experiences with fluorescence guided resection of malignant glioma", Proc. SPIE 4166, Laser Florence '99: A Window on the Laser Medicine World, (28 June 2000); https://doi.org/10.1117/12.389472

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