Effect of He-Ne laser irradiation on spontaneous contractive activity and basal tone level of rat portal vein

Nikolai N. Petrishchev; Valeria V. Barabanova; Irina A. Mikhailova; Svetlana G. Chephu

doi:10.1117/12.405916

3 November 2000 Effect of He-Ne laser irradiation on spontaneous contractive activity and basal tone level of rat portal vein

Nikolai N. Petrishchev, Valeria V. Barabanova, Irina A. Mikhailova, Svetlana G. Chephu

Author Affiliations +

Proceedings Volume 4159, Effects of Low-Power Light on Biological Systems V; (2000) https://doi.org/10.1117/12.405916
Event: EOS/SPIE European Biomedical Optics Week, 2000, Amsterdam, Netherlands

Abstract

To study the effect of He-Ne irradiation (632.8 nm, 15 mW/cm²) on spontaneous contractive activity the fragments of rat portal vein weremounted isometrically in Krebs buffer. Irradiation of vessel fragments by He-Ne laser during 3,5 and 10 min caused the decrease of ton up to 50%, which lasted in postirradiation period (the observation time - 10 min). The frequency of phasic and tonic contractions did not change, but the amplitude increased up to 40% as compared to the initial level. The decreased basal tone level and the increased amplitude of phasic oscillations lasted in postirradiation period. Adding NO synthasa blocator (N - nitro-L-arginine) to Krebs solution before irradiation caused no significant changes mentioned above parameters. Irradiation and coputing of the same parameters of spontaneous contractive activity of vena porta caused no effects, mentioned in the absence of the blocator. From the results it is concluded that the decrease of tone is evoked by the increase of EDRF production and cGMP. The increase of amplitude of phasic and tonic contractions is connected with increase of Ca⁺⁺ entry in every contraction cycle as a result of membrane Ca⁺⁺ pool increase.

Citation Download Citation

Nikolai N. Petrishchev, Valeria V. Barabanova, Irina A. Mikhailova, and Svetlana G. Chephu "Effect of He-Ne laser irradiation on spontaneous contractive activity and basal tone level of rat portal vein", Proc. SPIE 4159, Effects of Low-Power Light on Biological Systems V, (3 November 2000); https://doi.org/10.1117/12.405916

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KEYWORDS

Veins

Helium neon lasers

Calcium

Laser tissue interaction

Radiation effects

Visible radiation

Magnesium

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