Experimental and theoretical optimization of laser-produced x-ray spectra for vascular imaging

Andrzej Krol; Zhiming Jiang; Zahia Ichalalene; Jean-Claude Kieffer; Charles C. Chamberlain; Ernest M. Scalzetti

doi:10.1117/12.384507

25 April 2000 Experimental and theoretical optimization of laser-produced x-ray spectra for vascular imaging

Andrzej Krol, Zhiming Jiang, Zahia Ichalalene, Jean-Claude Kieffer, Charles C. Chamberlain, Ernest M. Scalzetti

Proceedings Volume 3977, Medical Imaging 2000: Physics of Medical Imaging; (2000) https://doi.org/10.1117/12.384507
Event: Medical Imaging 2000, 2000, San Diego, CA, United States

Abstract

Experimental and theoretical studies of image quality using iodinated contrast agent and x-ray spectra generated by laser- based x-ray source were performed. A TableTop Terawatt (T³) laser (intensity: 10¹⁷ - 10¹⁹ W/cm^-2, pulse duration: 150 fs or 450 fs, with or without controlled pre-pulse) was used to crate x-ray source. Infrared and/or green beams were utilized. Ba, La, Ce, Nd, and Gd laser targets were used. For each target, a number of suitable filters was utilized to produce optimized x-ray spectra for a specific imaging task. The MTF function due to the focal spot was obtained. A simple theoretical model of x-ray detector response was developed. An index of image quality (Detective Image Quality) as well as a figure of merit for dual energy imaging FOM(DESA) were defined and optimized via x-ray spectrum manipulation. The optimum, for a specific imaging task, technique parameters such as: target/filter combination, focal spot size, laser-light wavelength and surface power density, laser pulse duration, pre-pulse delay and contrast ratio, and hot electrons temperature were obtained experimentally and confirmed theoretically. We found that an optimized laser-based x-ray source can outperform conventional x-ray tube-based source in application to vascular imaging in terms of contrast resolution and spatial resolution.

Citation Download Citation

Andrzej Krol, Zhiming Jiang, Zahia Ichalalene, Jean-Claude Kieffer, Charles C. Chamberlain, and Ernest M. Scalzetti "Experimental and theoretical optimization of laser-produced x-ray spectra for vascular imaging", Proc. SPIE 3977, Medical Imaging 2000: Physics of Medical Imaging, (25 April 2000); https://doi.org/10.1117/12.384507

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