Living chips for drug discovery

Tanya S. Kanigan; Colin J. H. Brenan; Serge Lafontaine; Luke Sosnowski; Peter Geoffrey Madden; Ian Warwick Hunter

doi:10.1117/12.380509

22 March 2000 Living chips for drug discovery

Tanya S. Kanigan, Colin J. H. Brenan, Serge Lafontaine, Luke Sosnowski, Peter Geoffrey Madden, Ian Warwick Hunter

Proceedings Volume 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing; (2000) https://doi.org/10.1117/12.380509
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

We have developed novel microarray technology for performing large numbers (up to 10⁶) of chemical and cell-based assays in parallel. This technology is particularly relevant to the high-throughput screening methods used by the pharmaceutical industry to identify potential drug candidates. In this paper we provide an overview of the system and its enabling technologies, including an economical manufacturing process for creating these microarrays, a fluorescence imaging system for detecting `hits', a fluid delivery system for loading arrays, and a method for mixing reagents.

Citation Download Citation

Tanya S. Kanigan, Colin J. H. Brenan, Serge Lafontaine, Luke Sosnowski, Peter Geoffrey Madden, and Ian Warwick Hunter "Living chips for drug discovery", Proc. SPIE 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing, (22 March 2000); https://doi.org/10.1117/12.380509

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