Monitoring laser treatment of port wine stains using phase-resolved optical Doppler tomography

Yonghua Zhao; Zhongping Chen; Christopher E. Saxer; Johannes F. de Boer; Boris Majaron; Wim Verkruysse; J. Stuart Nelson M.D.

doi:10.1117/12.384162

28 April 2000 Monitoring laser treatment of port wine stains using phase-resolved optical Doppler tomography

Yonghua Zhao, Zhongping Chen, Christopher E. Saxer, Johannes F. de Boer, Boris Majaron, Wim Verkruysse, J. Stuart Nelson M.D.

Author Affiliations +

Proceedings Volume 3915, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV; (2000) https://doi.org/10.1117/12.384162
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

We used a novel phase-resolved optical Doppler tomographic (ODT) technique, with very high flow velocity sensitivity and high spatial resolution, to image blood flow in port wine stain (PWS) birthmarks in human skin. The variance of blood flow velocity is used to locate the PWS vessels in addition to the regular ODT images. Our device combines an ODT system and laser so that PWS blood flow can be monitored in situ before and after treatment. To our knowledge, this is the first clinical application of ODT to provide a fast semi-quantitative evaluation of the efficacy of PWS laser therapy in situ and in real-time.

Citation Download Citation

Yonghua Zhao, Zhongping Chen, Christopher E. Saxer, Johannes F. de Boer, Boris Majaron, Wim Verkruysse, and J. Stuart Nelson M.D. "Monitoring laser treatment of port wine stains using phase-resolved optical Doppler tomography", Proc. SPIE 3915, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV, (28 April 2000); https://doi.org/10.1117/12.384162

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