Frequency dependence of the ablation of pig tissue with an IR-FEL: a microspectroscopic analysis

Francois Glotin; Jean-Michel Ortega; Jean Luc Poncy; Francoise Tourdes; Jean Louis Lefaix; Paul Dumas

doi:10.1117/12.366635

25 October 1999 Frequency dependence of the ablation of pig tissue with an IR-FEL: a microspectroscopic analysis

Francois Glotin, Jean-Michel Ortega, Jean Luc Poncy, Francoise Tourdes, Jean Louis Lefaix, Paul Dumas

Proceedings Volume 3775, Accelerator-based Sources of Infrared and Spectroscopic Applications; (1999) https://doi.org/10.1117/12.366635
Event: SPIE's International Symposium on Optical Science, Engineering, and Instrumentation, 1999, Denver, CO, United States

Abstract

Ablation of human tissue with an infrared laser tuned to the amide II band of proteins has proven to be especially efficient, with reduced collateral damage. In order to check for a specific non-thermal effect at this wavelength, we have irradiated pig tissues at different frequencies, corresponding to the amide I, amide II and phosphate ones, with a free-electron laser, and analyzed the damaged area using an infrared microspectrometer. The observation of a relative weakening of the relative peak intensity of the amide II band when irradiation has been tuned into its resonant frequency tends to demonstrate that the ablation process should be enhanced due to a resonant denaturation of structural proteins.

Citation Download Citation

Francois Glotin, Jean-Michel Ortega, Jean Luc Poncy, Francoise Tourdes, Jean Louis Lefaix, and Paul Dumas "Frequency dependence of the ablation of pig tissue with an IR-FEL: a microspectroscopic analysis", Proc. SPIE 3775, Accelerator-based Sources of Infrared and Spectroscopic Applications, (25 October 1999); https://doi.org/10.1117/12.366635

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