Multifrequency YAG:Nd laser for diagnosis of malignant tumors

Asatur A. Lalayan; Lusine Aydinyan; Ishkhan G. Harutyunyan; Hayro M. Galstian

doi:10.1117/12.336817

19 January 1999 Multifrequency YAG:Nd laser for diagnosis of malignant tumors

Asatur A. Lalayan, Lusine Aydinyan, Ishkhan G. Harutyunyan, Hayro M. Galstian

Proceedings Volume 3568, Optical Biopsies and Microscopic Techniques III; (1999) https://doi.org/10.1117/12.336817
Event: BiOS Europe '98, 1998, Stockholm, Sweden

Abstract

The spectral peculiarities of normal and tumor human tissues of different localization after sensitization by sodium fluorescein has been studied with help of multifrequency YAG:Nd laser. Fluorescence spectra of normal human tissue and breast, stomach, intestine, skin cancer at 355, 440 nm laser excitation were registered. The pharmacokinetic behavior of sodium fluorescein in normal and different tumor tissues has been investigated. The optimal time for diagnosis (12 - 18 hours after drug injection) was determined. The intensification of tumor tissue autofluorescence decreasing after sensitization of organisms by tumor seeking dye was observed. The electron excitation energy transfer from NAD(P)H to endogen chromophores or dyes localized in tumor has been discussed as possible reason of the observed phenomenon.

Citation Download Citation

Asatur A. Lalayan, Lusine Aydinyan, Ishkhan G. Harutyunyan, and Hayro M. Galstian "Multifrequency YAG:Nd laser for diagnosis of malignant tumors", Proc. SPIE 3568, Optical Biopsies and Microscopic Techniques III, (19 January 1999); https://doi.org/10.1117/12.336817

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