Calculation of local optical properties in highly scattering media using a-priori structural information for application to simultaneous NIR-MR breast examination

Vasilis Ntziachristos; Arjun G. Yodh; Mitchell D. Schnall; XuHui Ma; Britton Chance

doi:10.1117/12.334369

30 December 1998 Calculation of local optical properties in highly scattering media using a-priori structural information for application to simultaneous NIR-MR breast examination

Vasilis Ntziachristos, Arjun G. Yodh, Mitchell D. Schnall, XuHui Ma, Britton Chance

Author Affiliations +

Proceedings Volume 3566, Photon Propagation in Tissues IV; (1998) https://doi.org/10.1117/12.334369
Event: BiOS Europe '98, 1998, Stockholm, Sweden

Abstract

A single photon counting NIR imager designed to work simultaneously with an MRI scanner for concurrent NIR-MR mammography has recently been developed. The combination of imaging modalities aims in effectively investigating the competence of optical imaging as a stand along modality and as an MRI add-on in order to increase the sensitivity and specificity of the mammoraphic examination. In this work we focus on the second aim. We present the methodology developed to employ the MR anatomical information in order to simplify the forward problem and accurately calculate local tissue optical properties, by fitting the NIR data to this model. Derivation of local optical properties due to intrinsic or extrinsic may identify the existence of malignant and benign breast tissue NIR signatures. We have evaluated the performance of the solver with experimental measurements, also presented here, from models with known absorption perturbations. The average quantification error of absolute absorption of local lesions has been found to be less than 10% in simple models and algorithm convergence is always ensured.

Citation Download Citation

Vasilis Ntziachristos, Arjun G. Yodh, Mitchell D. Schnall, XuHui Ma, and Britton Chance "Calculation of local optical properties in highly scattering media using a-priori structural information for application to simultaneous NIR-MR breast examination", Proc. SPIE 3566, Photon Propagation in Tissues IV, (30 December 1998); https://doi.org/10.1117/12.334369

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