Pharmacokinetic imaging of pediatric solid tumors

Wilburn E. Reddick; Sihong Wang; Sue C. Kaste

doi:10.1117/12.312557

3 July 1998 Pharmacokinetic imaging of pediatric solid tumors

Wilburn E. Reddick, Sihong Wang, Sue C. Kaste

Proceedings Volume 3337, Medical Imaging 1998: Physiology and Function from Multidimensional Images; (1998) https://doi.org/10.1117/12.312557
Event: Medical Imaging '98, 1998, San Diego, CA, United States

Abstract

Previously developed empirical analyses of dynamic contrast- enhanced MR imaging (DEMRI) studies have provided a more quantitative and accurate measure of solid tumor response. However, empirically based methods do not generalize easily to other solid tumors, and changes in the parameters during therapy are hard to relate to physiological mechanisms. This study compares the kinetic parameters from a two-compartment pharmacokinetic (PK) model of MR contrast agent accumulation with disease free survival rates after surgery and investigates the serial changes in these parameters over the course of therapy in thirty-five patients with osteosarcoma. The PK model allowed us to directly determine the relationship between the first-order permeability rate constant (k₂₁) of the model and histologic assessment of response. A Cox proportional hazards model was used to compare the average k₂₁ immediately prior to surgery and was determined to be significantly related to disease free survival. A linear regression analysis between the average k₂₁ at presentation and the resulting change in average k₂₁ during therapy revealed a statistically significant relationship corresponding to greater delivery of contrast agent. Larger regional access at presentation corresponded to larger decreases in access during therapy, which is consistent with the hypothesis that greater regional access at presentation should correspond to greater response to the chemotherapeutic agents.

Citation Download Citation

Wilburn E. Reddick, Sihong Wang, and Sue C. Kaste "Pharmacokinetic imaging of pediatric solid tumors", Proc. SPIE 3337, Medical Imaging 1998: Physiology and Function from Multidimensional Images, (3 July 1998); https://doi.org/10.1117/12.312557

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KEYWORDS

Tumors

Surgery

Magnetic resonance imaging

Solids

Statistical analysis

Tissues

Hazard analysis

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