Relief of vasospasm by intravascular ultraviolet irradiation

Kanji Nakai; Yuji Morimoto; Hirotaka Ito M.D.; Kimito Kominami M.D.; Hirotaka Matsuo M.D.; Tsunenori Arai; Makoto Kikuchi

doi:10.1117/12.308205

13 May 1998 Relief of vasospasm by intravascular ultraviolet irradiation

Kanji Nakai, Yuji Morimoto, Hirotaka Ito M.D., Kimito Kominami M.D., Hirotaka Matsuo M.D., Tsunenori Arai, Makoto Kikuchi

Author Affiliations +

Proceedings Volume 3254, Laser-Tissue Interaction IX; (1998) https://doi.org/10.1117/12.308205
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

We investigated the photovasorelaxation with intravascular transluminal irradiation using in vivo model. A 2.5 Fr. catheter was inserted in the femoral artery of a rabbit under anesthesia. A 400 micrometers diameter quartz fiber was inserted through the catheter. The catheter was withdrawn from the distal end to the proximal end of the exposed femoral artery without laser irradiation in order to observe the mechanical dilation by the procedure. The femoral artery lumen was irradiated by a Helium-Cadmium(He-Cd) laser (wavelength; 325 nm) with 8 mW through the fiber during 30 s. We carried out that the laser irradiation produced vasorelaxation (185% on the average) compared with mechanical vasodilation (150% on the average) with angiography. The results suggest that intravascular transluminal irradiation with low-power UV laser might be applicable to the relief of acute arterial vasospasm.

Citation Download Citation

Kanji Nakai, Yuji Morimoto, Hirotaka Ito M.D., Kimito Kominami M.D., Hirotaka Matsuo M.D., Tsunenori Arai, and Makoto Kikuchi "Relief of vasospasm by intravascular ultraviolet irradiation", Proc. SPIE 3254, Laser-Tissue Interaction IX, (13 May 1998); https://doi.org/10.1117/12.308205

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