Photodynamic therapy with photoactivated aluminum disulfonated phthalocyanine and cellular immune response

Gianfranco L. Canti; Rinaldo Cubeddu; Paola Taroni; Gianluca Valentini

doi:10.1117/12.308158

13 May 1998 Photodynamic therapy with photoactivated aluminum disulfonated phthalocyanine and cellular immune response

Gianfranco L. Canti, Rinaldo Cubeddu, Paola Taroni, Gianluca Valentini

Proceedings Volume 3254, Laser-Tissue Interaction IX; (1998) https://doi.org/10.1117/12.308158
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

Photodynamic therapy (PDT) of cancer is based on the systemic administration of photosensitive drugs followed by exposure of the tumor mass to light of particular wavelength. The combination of drug uptake in malignant tissues and selective delivery of laser-generated light provides for an effective therapy with efficient tumor cytotoxicity and minimal normal tissue damage. There are various studies on the effect of photoactivated photosensitizers on host immune response in tumor bearing mice. Since immunity is important in the control of tumor growth and spreading in our laboratory we examine the effect of PDT on immune compartment. Spleen hyperplasia as well as spleen and marrow hypercellularities were observed in tumor bearing mice treated with Aluminum Disulfonated Phthalocyanine (AlS₂Pc) and laser light. Phytohaemagglutinin (T lymphocytes mitogen) and Lypolisaccaride (B lymphocytes mitogen), stimulation of spleen lymphocytes caused an increase in blast transformation in tumor bearing mice. Furthermore splenocytes and macrophages collected from mice treated with PDT were cytotoxic in vivo (Winn Assay) parental against tumor cells. The results observed suggest that PDT is able to modulate the immune response and oncological patients treated with PDT could become immune versus a relapse or versus the minimal residual disease.

Citation Download Citation

Gianfranco L. Canti, Rinaldo Cubeddu, Paola Taroni, and Gianluca Valentini "Photodynamic therapy with photoactivated aluminum disulfonated phthalocyanine and cellular immune response", Proc. SPIE 3254, Laser-Tissue Interaction IX, (13 May 1998); https://doi.org/10.1117/12.308158

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available