Efficiency of laser action on hemoglobin and oxyhemoglobin in skin blood vessels

Mustafo M. Asimov; Rustam M. Asimov; Anatoly Nikolaevich Rubinov

doi:10.1117/12.308190

13 May 1998 Efficiency of laser action on hemoglobin and oxyhemoglobin in skin blood vessels

Mustafo M. Asimov, Rustam M. Asimov, Anatoly Nikolaevich Rubinov

Proceedings Volume 3254, Laser-Tissue Interaction IX; (1998) https://doi.org/10.1117/12.308190
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

The efficiency of light absorption by oxyhemoglobin and deoxyhemoglobin in cutaneous blood vessels in dependence of the radiation wavelength and optical properties of the tissue is investigated. The main goal is to develop the practical application of long pulse flashlamp-pumped dye lasers in the treatment of different cutaneous lesions, based on the selective photothermolysis. The spectra of laser action both on oxyhemoglobin and deoxyhemoglobin of blood vessels at different depths of the tissue layer were calculated using the Kubelka-Munk optical model of the tissue. The obtained results allow to choose the proper wavelength of laser radiation for the selective and efficient influence on the blood chromophores. It is shown that for blood vessels located in tissue up to the depth of 2500 (mu) the action spectra of laser radiation follow the shape of the Q - absorption bands of oxyhemoglobin and deoxyhemoglobin. At deeper layers the action spectra become very narrow ((delta) (lambda) on the order of magnitude 25 - 30 nm) and shift to the long wavelength with maximum at 585 nm and 570 nm for oxyhemoglobin and deoxyhemoglobin, accordingly. The action spectra in the near infrared region remain very broad and cover the range from 600 nm to 1200 nm. It is shown that these bands play the dominant role in the absorption of laser radiation in deeper layers of tissue.

Citation Download Citation

Mustafo M. Asimov, Rustam M. Asimov, and Anatoly Nikolaevich Rubinov "Efficiency of laser action on hemoglobin and oxyhemoglobin in skin blood vessels", Proc. SPIE 3254, Laser-Tissue Interaction IX, (13 May 1998); https://doi.org/10.1117/12.308190

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