Fluorescent products in high-density lipoproteins (HDL) and their association with other lipid peroxide products (LPPs)

Swiatoslav L. Plavinski; Alexandr S. Kuznetsov; Yurij I. Kopilevich; Alexander A. Svetlykh; Nikita O. Melnikov

doi:10.1117/12.297938

13 January 1998 Fluorescent products in high-density lipoproteins (HDL) and their association with other lipid peroxide products (LPPs)

Swiatoslav L. Plavinski, Alexandr S. Kuznetsov, Yurij I. Kopilevich, Alexander A. Svetlykh, Nikita O. Melnikov

Author Affiliations +

Proceedings Volume 3196, Optical and Imaging Techniques for Biomonitoring III; (1998) https://doi.org/10.1117/12.297938
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

The lipid peroxidation products of the lipofuscin type can be measured in plasma with the help of fluorimeters. Such products are increasing during whole plasm oxidation in parallel with other indices of lipid peroxidation damage. Preformed fluorescent products are located in all lipoprotein classes. The study of lipofuscin-type pigments fluorescence in HDL showed, that they contain substantial amounts of fluorescent compounds and that it rises in parallel with concentration of other lipid peroxidation products, especially thiobarbituric acid-reacting substances. Neither total plasma cholesterol, nor triglycerides influenced content of fluorescent products in HDL. The HDL subfractions contained different types of the fluorescent products but the bulk of these lipoproteins were almost free of them. The obtained data show that measurement of lipofuscin-type fluorescence in HDL gives a good and sensitive index of these lipoproteins damage by peroxidation.

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Swiatoslav L. Plavinski, Alexandr S. Kuznetsov, Yurij I. Kopilevich, Alexander A. Svetlykh, and Nikita O. Melnikov "Fluorescent products in high-density lipoproteins (HDL) and their association with other lipid peroxide products (LPPs)", Proc. SPIE 3196, Optical and Imaging Techniques for Biomonitoring III, (13 January 1998); https://doi.org/10.1117/12.297938

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