Signal transduction in chemosensors of modified cyclodextrins

Akihiko Ueno; Hiroshi Ikeda; Taiyo Aoyagi

doi:10.1117/12.273523

7 May 1997 Signal transduction in chemosensors of modified cyclodextrins

Akihiko Ueno, Hiroshi Ikeda, Taiyo Aoyagi

Proceedings Volume 2980, Advances in Fluorescence Sensing Technology III; (1997) https://doi.org/10.1117/12.273523
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

Artificial hosts such as crown ethers, cryptands, calixarenes, and others have been used for detecting metal ions or others mostly in organic solvents. On the other hand, we prepared many cyclodextrin derivatives bearing one or two chromophores and found that they can be used as sensors for detecting various organic compounds in aqueous solution. Cyclodextrins (CDs) are spectroscopically inert, but they can be converted into spectroscopically active hosts by modification with appropriate chromophores. The modified CDs usually form self-inclusion complexes by including one or two chromophore moieties in their cavities. Fluorophore-modified CDs exhibit guest-responsive fluorescence intensity variation and the mechanism for signal transduction from guest binding to fluorescence response involves the conformational changes of modified CDs as shown by the exclusion of the fluorophore moiety from inside to outside of the CD cavity in guest binding. Here, we show molecular recognition and sensing abilities of various new types of modified CDs which bear naphthalene, dansyl, p-(dimethylamino)benzoyl or pyrene unit as a fluorescent moiety.

Citation Download Citation

Akihiko Ueno, Hiroshi Ikeda, and Taiyo Aoyagi "Signal transduction in chemosensors of modified cyclodextrins", Proc. SPIE 2980, Advances in Fluorescence Sensing Technology III, (7 May 1997); https://doi.org/10.1117/12.273523

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available