Fluorescence probe for cervical examination during various reproductive states

Wenling S. Glassman; Qin-Ping Liao; Shao-Qing Shi; Linda Goodrum; Gayle Olson; Elizabeth Martin; George Saade; Robert E. Garfield

doi:10.1117/12.273513

7 May 1997 Fluorescence probe for cervical examination during various reproductive states

Wenling S. Glassman, Qin-Ping Liao, Shao-Qing Shi, Linda Goodrum, Gayle Olson, Elizabeth Martin, George Saade, Robert E. Garfield

Author Affiliations +

Proceedings Volume 2980, Advances in Fluorescence Sensing Technology III; (1997) https://doi.org/10.1117/12.273513
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

These studies represent further investigations that have been done utilizing the fluorescence from pyridinoline, one of the major crosslinks of type I and III collagen, to evaluate cervical connective tissue changes during various female reproductive periods. Based on our previous studies, a prototype instrument has been constructed. The instrument was specifically designed for the purpose of vaginal examination of cervical connective tissue by measuring light induced fluorescence directly from the surface of the external os of the cervix. The studies were carried out on nonpregnant rats, rats during gestation at different periods, rats at different times during postpartum, and rats during preterm birth after being treated with antiprogesterone drugs. A study has also been done on humans during pregnancy and postpartum. The results parallel previous investigations that have used various invasive methods to analyze cervical extensibility, cervical collagen content and collagenase. In consideration of the important role of the collagen fibers and their turnover in the process of cervical function during pregnancy (softening or ripening at term), this method could be a useful tool for evaluating treatment strategies of the cervix. Moreover, the instrument could serve as a device for the non-invasive estimation of cervical status in the clinic and the diagnosis of the changes in the cervix during the preparation for labor.

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Wenling S. Glassman, Qin-Ping Liao, Shao-Qing Shi, Linda Goodrum, Gayle Olson, Elizabeth Martin, George Saade, and Robert E. Garfield "Fluorescence probe for cervical examination during various reproductive states", Proc. SPIE 2980, Advances in Fluorescence Sensing Technology III, (7 May 1997); https://doi.org/10.1117/12.273513

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