Laser-induced thermotherapy (LITT) for the treatment of liver metastases: the correlation of Gd-DTPA-enhanced magnetic resonance imaging (MRI) and histomorphological findings in the chronic model

Christoph Martin Isbert; Christoph-Thomas Germer; Dirk Albrecht; Andreas Schilling; Antje Heiniche M.D.; Andre Roggan; Karl Juergen Wolf; Gerhard J. Mueller; Heinz-Johannes Buhr

doi:10.1117/12.275089

22 May 1997 Laser-induced thermotherapy (LITT) for the treatment of liver metastases: the correlation of Gd-DTPA-enhanced magnetic resonance imaging (MRI) and histomorphological findings in the chronic model

Christoph Martin Isbert, Christoph-Thomas Germer, Dirk Albrecht, Andreas Schilling, Antje Heiniche M.D., Andre Roggan, Karl Juergen Wolf, Gerhard J. Mueller, Heinz-Johannes Buhr

Author Affiliations +

Proceedings Volume 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII; (1997) https://doi.org/10.1117/12.275089
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

The purpose of the study was to evaluate Gd-DTPA-enhanced MRI for the follow-up of laser-induced thermotherapy (LITT) in the treatment of liver metastases. Interstitial laser-induced thermotherapy (LITT) was performed in 55 chinchilla bastard rabbits with a Nd:YAG laser and a specially developed diffuser tip applicator. The animals were examined at different times using MRI and histological methods. T1-weighted spin-echo sequences were made with gadolinium-DTPA and submitted to correlation analysis. The analysis yielded a good correlation (r equals 0.96) between the largest lesion diameters. Lesions showed discontinuous regeneration kinetics with a 41% volume reduction 1 month after LITT. MRI of the lesion directly after LITT showed a hyperintense transition zone. Following the application of intravenous contrast medium, transition zone enhancement was first seen 72 - 96 hours after LITT. Even after 6 months, the laser-induced lesion is visualized as a non-enhanced area. Lesion regeneration followed the principles of wound healing. It is concluded that gadolinium-DTPA- enhanced MRI yielded definitive criteria for the follow-up assessment of LITT.

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Christoph Martin Isbert, Christoph-Thomas Germer, Dirk Albrecht, Andreas Schilling, Antje Heiniche M.D., Andre Roggan, Karl Juergen Wolf, Gerhard J. Mueller, and Heinz-Johannes Buhr "Laser-induced thermotherapy (LITT) for the treatment of liver metastases: the correlation of Gd-DTPA-enhanced magnetic resonance imaging (MRI) and histomorphological findings in the chronic model", Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); https://doi.org/10.1117/12.275089

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