Photodynamic therapy of head and neck tumors

Elena G. Vakoulovskaya M.D.; Victor V. Shental M.D.; N. A. Abdoullin; Yury P. Kuvshinov; T. D. Tabolinovskaia; N. J. Edinak; Boris K. Poddubny; V. L. Lioubaev; V. P. Boikov; T. T. Kondratjeva; Gennadii A. Meerovich; Alexander A. Stratonnikov; Kirill G. Linkov; Valery V. Agafonov

doi:10.1117/12.260763

4 December 1996 Photodynamic therapy of head and neck tumors

Elena G. Vakoulovskaya M.D., Victor V. Shental M.D., N. A. Abdoullin, Yury P. Kuvshinov, T. D. Tabolinovskaia, N. J. Edinak, Boris K. Poddubny, V. L. Lioubaev, V. P. Boikov, T. T. Kondratjeva, Gennadii A. Meerovich, Alexander A. Stratonnikov, Kirill G. Linkov, Valery V. Agafonov

Author Affiliations +

Proceedings Volume 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II; (1996) https://doi.org/10.1117/12.260763
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

This paper deals with the results of stage 1 clinical trials for sulfated aluminum phthalocyanine (PHS) (Photosens, Russia) in 1994-1996. The results of photodynamic therapy (PDT) of head and neck tumors (HNT), side effects and ways of their correction and prevention, as well as changes in doses of injected photosensitizer (PS), regimes of light irradiation, choice of laser and type of irradiation (surface or interstitial) are discussed. PDT have been provided in 42 patients (93 tumor sites) with different head and neck tumors. Fluorescent diagnostics of tumor, accumulation of PS in tumor, adjacent tissue has been fulfilled. Total 78 PDT sessions have been done. As a source of light we used: quantoscope, solid laser, krypton laser, tunable dye laser, He-Ne-laser. In 38 tumor sites (21 patients) -- 40.8% -- we had clinical response, in 27 tumor sites (16 patients) -- 29.0% -- we had partial response, in 28 tumor sites (8 patients) -- 30.2% -- we had no response. Our experience shows pronounced efficacy of PDT for HNT, except of melanoma. Providing PDT twice with the interval 24 - 72 hours when retention of PS is sufficient for treatment, did additive effect to the tumor, but didn't increase adjacent tissue damage.

Citation Download Citation

Elena G. Vakoulovskaya M.D., Victor V. Shental M.D., N. A. Abdoullin, Yury P. Kuvshinov, T. D. Tabolinovskaia, N. J. Edinak, Boris K. Poddubny, V. L. Lioubaev, V. P. Boikov, T. T. Kondratjeva, Gennadii A. Meerovich, Alexander A. Stratonnikov, Kirill G. Linkov, and Valery V. Agafonov "Photodynamic therapy of head and neck tumors", Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); https://doi.org/10.1117/12.260763

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available