Effect of laser wavelengths and HpD on diffuse reflectance of tumor surface in mice

Xiaoyuan Li; Runchu Tan; Hongmin Shi; Huajiang Wei

doi:10.1117/12.251957

23 September 1996 Effect of laser wavelengths and HpD on diffuse reflectance of tumor surface in mice

Xiaoyuan Li, Runchu Tan, Hongmin Shi, Huajiang Wei

Proceedings Volume 2887, Lasers in Medicine and Dentistry: Diagnostics and Treatment; (1996) https://doi.org/10.1117/12.251957
Event: Photonics China '96, 1996, Beijing, China

Abstract

We report the effect of laser wavelengths and HpD on diffuse reflectance of tumor surface in mice. Three kinds of lasers of six different wavelengths and hemetoporphyrin derivative as photosensitizer were used in the experiment. Tumor- bearing mice were divided into two groups. The mice of one group were given an i.p. injection of HpD 10 mg/kg. 24 hours later, the laser diffuse reflectance of tumor surface of the mice of two groups were measured by a single integrating sphere system with laser in six wavelengths. The results of measurement showed that significant difference of diffuse reflectance on tumor surface between the visible laser light and infrared laser light were observed. There was no significant difference in diffuse reflectance on tumor surface with and without i.p. injection of HpD. So it is unnecessary to consider the effect of HpD when calculating the actual laser dose irradiated into the tumor. The diffuse reflectance of tumor surface reaches its maximum at 1060nm wavelength, as twice as at 514.5 nm wavelength. It is hence concluded that diffuse reflectance should be taken into consideration when calculating the actual laser density for irradiation on tumors.

Citation Download Citation

Xiaoyuan Li, Runchu Tan, Hongmin Shi, and Huajiang Wei "Effect of laser wavelengths and HpD on diffuse reflectance of tumor surface in mice", Proc. SPIE 2887, Lasers in Medicine and Dentistry: Diagnostics and Treatment, (23 September 1996); https://doi.org/10.1117/12.251957

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KEYWORDS

Tumors

Diffuse reflectance spectroscopy

Reflectivity

Tissues

Laser therapeutics

Laser tissue interaction

Natural surfaces

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