Endoscopic photodynamic therapy of tumors using gold vapor laser

Yury P. Kuvshinov; Boris K. Poddubny; Andrei F. Mironov; Igor V. Ponomarev; V. V. Shental; Yu. E. Vaganov; T. T. Kondratjeva; E. V. Trofimova

doi:10.1117/12.229488

8 January 1996 Endoscopic photodynamic therapy of tumors using gold vapor laser

Yury P. Kuvshinov, Boris K. Poddubny, Andrei F. Mironov, Igor V. Ponomarev, V. V. Shental, Yu. E. Vaganov, T. T. Kondratjeva, E. V. Trofimova

Author Affiliations +

Proceedings Volume 2728, CIS Selected Papers: Laser Use in Oncology; (1996) https://doi.org/10.1117/12.229488
Event: CIS Selected Papers: Laser Use in Oncology, 1995, -, Russian Federation

Abstract

Compact sealed-off gold vapor laser (GVL) with 2 W average power and 628 nm wavelength was used for endoscopic photodynamic therapy in 20 patients with different tumors in respiratory system and upper gastrointestinal tract. Russian-made hematoporphyrin derivative (Hpd) `Photohem' was used as a photosensitizer. It was given intravenously at a dose of 2 - 2.5 mg/kg body weight 48 hours prior to tumor illumination with 628 nm light from GVL. Intermittent irradiation with GVL was done through flexible endoscope always under local anaesthesia at a power of 200 - 400 mW/sm² and a dose of 150 - 400 J/sm². 80% patients showed complete or partial response depending on stage of tumor. In cases of early gastric cancer all patients had complete remission with repeated negative biopsies. No major complication occurred.

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Yury P. Kuvshinov, Boris K. Poddubny, Andrei F. Mironov, Igor V. Ponomarev, V. V. Shental, Yu. E. Vaganov, T. T. Kondratjeva, and E. V. Trofimova "Endoscopic photodynamic therapy of tumors using gold vapor laser", Proc. SPIE 2728, CIS Selected Papers: Laser Use in Oncology, (8 January 1996); https://doi.org/10.1117/12.229488

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