Photodynamic therapy using a diode laser with mono-L-aspartyl chlorin e6 (NPe6)

Kinya Furukawa M.D.; Tohichiro Katsumi; Hiroshi Shibuya; Tetsuya Okunaka; Yukari Kuroiwa; Yoshiteru Ii; Akira Kaneda; Kouichi Saito; Chimori Konaka; Katsuo Aizawa; Harubumi Kato M.D.

doi:10.1117/12.237541

2 April 1996 Photodynamic therapy using a diode laser with mono-L-aspartyl chlorin e6 (NPe6)

Kinya Furukawa M.D., Tohichiro Katsumi, Hiroshi Shibuya, Tetsuya Okunaka, Yukari Kuroiwa, Yoshiteru Ii, Akira Kaneda, Kouichi Saito, Chimori Konaka, Katsuo Aizawa, Harubumi Kato M.D.

Author Affiliations +

Proceedings Volume 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V; (1996) https://doi.org/10.1117/12.237541
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

The authors developed a new high-power red laser diode system (Matsushita Industrial Equipment Co., Ltd., Osaka) for photodynamic therapy (PDT) with mono-L-aspartyl chlorin e6 (NPe6, Meiji Seika Kaisha LTD.). The laser wavelength was adjusted to 664 nm and the power output could be varied in the range of 50-500 mW at the fiber tip in a continuous wave (cw) mode. The delivered energy could be adjusted from 50 - 1000 J. The system has a size of 49 by 20 by 40 cm, weighs 20 kg, and is readily portable. It runs on 100 V current. The laser power is easily controlled and the wavelength is stable (less than plus or minus 0.2 nm). The output beam is delivered via a quartz fiber. Furthermore, the full width at half-maximum power is less than 2 nm, which enables uniform, high-density photoirradiation. The power density distribution of the laser, analyzed by a CCD camera, was uniform throughout the photoirradiated field. In an animal study, tumor-bearing Balb/c mice were treated with the diode laser 5 hours after intravenous administration of NPe6 at a dose of 1.25 to 12.5 mg/kg i.v.. Total photoirradiation ranged from 3.13 to 250 J/cm² which the energy density was adjusted to 100 mW/cm². Percentages of cures were determined histopathologically from numbers of mice apparently disease-free 1 week after treatment. The results show that a laser energy of more than 12.5 J/cm² was necessary to obtain 90% tumor cure rate at a maximum dose of NPe6 (12.5 mg/kg) and NPe6 dose of more than 2.5 mg/kg was necessary to obtain 90% cure rate at high laser energy of 200 J/cm².

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Kinya Furukawa M.D., Tohichiro Katsumi, Hiroshi Shibuya, Tetsuya Okunaka, Yukari Kuroiwa, Yoshiteru Ii, Akira Kaneda, Kouichi Saito, Chimori Konaka, Katsuo Aizawa, and Harubumi Kato M.D. "Photodynamic therapy using a diode laser with mono-L-aspartyl chlorin e6 (NPe6)", Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); https://doi.org/10.1117/12.237541

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KEYWORDS

Photodynamic therapy

Semiconductor lasers

Tumors

Laser energy

Laser systems engineering

Continuous wave operation

Laser therapeutics

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