Clinical detection studies of Barrett's metaplasia and oesophageal adenocarcinoma by means of laser-induced fluorescence

Annika M.K. Nilsson; Christer Stael von Holstein; Stefan Andersson-Engels; Roger Willen; Bruno Walther; Katarina Svanberg M.D.

doi:10.1117/12.228903

27 December 1995 Clinical detection studies of Barrett's metaplasia and oesophageal adenocarcinoma by means of laser-induced fluorescence

Annika M.K. Nilsson, Christer Stael von Holstein, Stefan Andersson-Engels, Roger Willen, Bruno Walther, Katarina Svanberg M.D.

Author Affiliations +

Proceedings Volume 2627, Optical Biopsies; (1995) https://doi.org/10.1117/12.228903
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Five patients with Barrett's metaplastic epithelium were investigated by means of laser- induced fluorescence after low-dose i.v. injection (0.35 mg/kg b.w.) of Photofrin^R in connection with endoscopy procedures. The excitation wavelength was 405 nm. Recorded fluorescence spectra were evaluated by forming ratios with the photosensitizer fluorescence as numerator and the autofluorescence as denominator. Two patients had no evidence of malignancy and their fluorescence ratios were consequently rather small, whereas the other three patients had adenocarcinoma and showed considerably higher ratios. The results indicate that laser-induced fluorescence can be used as an aid in detecting malignant transformations in Barrett's metaplasia.

Citation Download Citation

Annika M.K. Nilsson, Christer Stael von Holstein, Stefan Andersson-Engels, Roger Willen, Bruno Walther, and Katarina Svanberg M.D. "Clinical detection studies of Barrett's metaplasia and oesophageal adenocarcinoma by means of laser-induced fluorescence", Proc. SPIE 2627, Optical Biopsies, (27 December 1995); https://doi.org/10.1117/12.228903

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