Comparison of photobleaching and fluence rate effects in PpIX and BPD-MA photosensitization of rat bladder tumor in vivo

Seiichi Iinuma; Georges A. Wagnieres; Kevin T. Schomacker; Mike Bamberg; Tayyaba Hasan

doi:10.1117/12.209886

22 May 1995 Comparison of photobleaching and fluence rate effects in PpIX and BPD-MA photosensitization of rat bladder tumor in vivo

Seiichi Iinuma, Georges A. Wagnieres, Kevin T. Schomacker, Mike Bamberg, Tayyaba Hasan

Author Affiliations +

Proceedings Volume 2391, Laser-Tissue Interaction VI; (1995) https://doi.org/10.1117/12.209886
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

Photobleaching of 5-aminolevulinic acid (ALA) -induced protoporphyrin IX (PpIX) and benzoporphyrin derivative-monoacid ring A (BPD-MA) was investigated using an orthotopic rat bladder tumor model. For both photosensitizers used, the photobleaching rate constant was not fluence- rate-dependent under conditions that photodynamic response was fluence rate-dependent. These data suggest that photobleaching pathways may be independent of the photochemical paths involved in tissue destruction. The fluorescence spectrum was followed during irradiation by using laser-induced fluorescence method and a build-up of photoproducts of PpIX was observed whereas no fluorescence of photoproducts was obtained in the case of BPD-MA.

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Seiichi Iinuma, Georges A. Wagnieres, Kevin T. Schomacker, Mike Bamberg, and Tayyaba Hasan "Comparison of photobleaching and fluence rate effects in PpIX and BPD-MA photosensitization of rat bladder tumor in vivo", Proc. SPIE 2391, Laser-Tissue Interaction VI, (22 May 1995); https://doi.org/10.1117/12.209886

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