5-aminolaevulinic acid for fluorescence diagnosis and photodynamic therapy of bronchial cancer: a case report

Fernando Gamarra; Reinhold Baumgartner; Herbert G. Stepp; Kai Rick; A. Leberig; Rudolf M. Huber

doi:10.1117/12.203383

1 March 1995 5-aminolaevulinic acid for fluorescence diagnosis and photodynamic therapy of bronchial cancer: a case report

Fernando Gamarra, Reinhold Baumgartner, Herbert G. Stepp, Kai Rick, A. Leberig, Rudolf M. Huber

Author Affiliations +

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203383
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

Five-aminolaevulinic acid (ALA) was applied orally and by aerosol inhalation to one patient in order to check the feasibility of photodynamic therapy (PDT) and photodynamic fluorescence diagnosis (PDD) of lung cancer. For PDD, ALA was given by inhalation using a conventional jet nebulizer. Protoporphyrin IX (PP IX)-fluorescence in the bronchial mucosa and the tumor was assessed visually and by spectroscopy using an optical multichannel analyzer. At a second session ALA was given orally and PDD as well as PDT were performed. The therapeutic effect on the tumor was controlled by bronchoscopy 5 and 12 weeks after PDT. Inhalative and oral application of ALA were both well tolerated. No adverse effects were observed. PP IX- fluorescence could be easily detected 3 h after ALA administered by inhalation or 5 h after ALA orally. Fluorescence ratio between tumor and normal tissues was better after the oral administration of ALA. Five and twelve weeks after PDT, marked reduction of tumor volume and recanalization of the left upper lobe were found.

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Fernando Gamarra, Reinhold Baumgartner, Herbert G. Stepp, Kai Rick, A. Leberig, and Rudolf M. Huber "5-aminolaevulinic acid for fluorescence diagnosis and photodynamic therapy of bronchial cancer: a case report", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203383

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