Corneal photoablation with a scanning beam of 213 nm radiation for alteration of refraction: a three-month follow up study of the rabbit

Per G. Soederberg; Takaaki Matsui; Fabrice Manns; Jin-Hui Shen; Jean-Marie A. Parel; Jean-Marc Legeais M.D.; Michele Savoldelli; Isabelle Drubaix

doi:10.1117/12.199262

12 January 1995 Corneal photoablation with a scanning beam of 213 nm radiation for alteration of refraction: a three-month follow up study of the rabbit

Per G. Soederberg, Takaaki Matsui, Fabrice Manns, Jin-Hui Shen, Jean-Marie A. Parel, Jean-Marc Legeais M.D., Michele Savoldelli, Isabelle Drubaix

Author Affiliations +

Proceedings Volume 2330, Lasers in Ophthalmology II; (1995) https://doi.org/10.1117/12.199262
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

A scanning pulsed beam at 213 nm creates predictable correction of myopia but the surgical procedure with the presently used laser system is not yet sufficiently safe to proceed to human clinical trials. It was found that a 70% overlap of approximate active spot size provides a refractive change as predicted 1 week after ablation. There was a minimal transient increase of IOP shortly after the ablation. There was an immediate swelling of the cornea after the ablation that gradually decreased during the following 12 weeks. The corneal epithelium did not heal until around 4 - 7 weeks after the ablation. The epithelium stained with fluorescein late after the ablation. When considerable haze was seen it decreased towards the end of the 12 weeks of observation. Approximately 30% of ablated corneas showed vessel ingrowth at 12 weeks after ablation. The 213 nm beam was obtained by frequency quintupling of the output of a Nd-Yag laser. The beam was moved with an X-Y scanner.

Citation Download Citation

Per G. Soederberg, Takaaki Matsui, Fabrice Manns, Jin-Hui Shen, Jean-Marie A. Parel, Jean-Marc Legeais M.D., Michele Savoldelli, and Isabelle Drubaix "Corneal photoablation with a scanning beam of 213 nm radiation for alteration of refraction: a three-month follow up study of the rabbit", Proc. SPIE 2330, Lasers in Ophthalmology II, (12 January 1995); https://doi.org/10.1117/12.199262

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