New fluorinated photosensitizers based on tetrakis(hydroxyphenyl) porphyrins

Raymond Bonnett; S. Phinda Songca

doi:10.1117/12.199138

12 January 1995 New fluorinated photosensitizers based on tetrakis(hydroxyphenyl) porphyrins

Raymond Bonnett, S. Phinda Songca

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199138
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

The potential advantages of fluorinated porphyrin photosensitizers are outlined. The syntheses of fluorinated analogues of sensitizers which are known to be active in vivo are described with particular reference to compounds of the tetrakis(hydroxyphenyl)porphyrin series. Three new fluorinated (hydroxyphenyl)porphyrins are prepared [5,10,15,20-tetrakis(2-fluoro-3- hydroxyphenyl)porphyrin; 5,10,15,20-tetrakis(2,4-difluoro-3-hydroxyphenyl)porphyrin; and 5,10,15,20-tetrakis(3,5-difluoro-4-hydroxyphenyl)porphyrin], and some of their relevant properties are described.

Citation Download Citation

Raymond Bonnett and S. Phinda Songca "New fluorinated photosensitizers based on tetrakis(hydroxyphenyl) porphyrins", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199138

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