New chlorin and bacteriochlorine-type photosensitizers for photodynamic therapy

Andrei N. Kozyrev; Alexandr V. Efimov; Ol'ga A. Efremova; Pavel Yu. Perepyolkin; Andrei F. Mironov

doi:10.1117/12.199158

12 January 1995 New chlorin and bacteriochlorine-type photosensitizers for photodynamic therapy

Andrei N. Kozyrev, Alexandr V. Efimov, Ol'ga A. Efremova, Pavel Yu. Perepyolkin, Andrei F. Mironov

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199158
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

New chlorins and bacteriochlorins as perspective sensitizers for photodynamic therapy were synthesized. The influence on the position and the character of the substituents on the sensitizer optical properties was studied. The series of water soluble chlorin p₆ derivatives with graded amphiphility were synthesized for studies on tumor accumulation. The influence of pH on sensitizer amphiphility was discussed. The photostability of water soluble chlorins and bacteriochlorins has been examined.

Citation Download Citation

Andrei N. Kozyrev, Alexandr V. Efimov, Ol'ga A. Efremova, Pavel Yu. Perepyolkin, and Andrei F. Mironov "New chlorin and bacteriochlorine-type photosensitizers for photodynamic therapy", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199158

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