Immune modulation using transdermal photodynamic therapy

Julia G. Levy; R. K. Chowdhary; Leslie G. Ratkay; Douglas Waterfield; Modestus Obochi; Simon Leong; David W. C. Hunt; Agnes H. Chan

doi:10.1117/12.199139

12 January 1995 Immune modulation using transdermal photodynamic therapy

Julia G. Levy, R. K. Chowdhary, Leslie G. Ratkay, Douglas Waterfield, Modestus Obochi, Simon Leong, David W. C. Hunt, Agnes H. Chan

Author Affiliations +

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199139
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

The photosensitizer benzoporphyrin derivative monoacid ring A (Verteporfin^R or BPD) has maximum absorption characteristics (690 nm) and biodistribution characteristics which permit activation of the drug in capillaries of the skin without causing skin photosensitivity (transdermal PDT). This permits targeting of cells in the circulation for selective ablation. Since BPD has been shown to accumulate preferentially in activated lymphocytes and monocytes, studies have been undertaken to determine the effect of transdermal PDT on murine models for rheumatoid arthritis (the MRL/lpr adjuvant enhanced model) and multiple sclerosis (the experimental allergic encephalomyelitis (EAE) model in PL mice). Localized transdermal PDT with BPD was found to be completely successful in preventing the development of adjuvant enhanced arthritis in the MRL/lpr mouse as well as improving the underlying arthritic condition of these animals. In the EAE model, in which an adoptive transfer system was used, it was found that transdermal PDT of recipients was effective in preventing EAE if treatments were implemented up to 24 hours after cell transfer but was not effective if given later, indicating the requirement for circulating T cells for effective treatment.

Citation Download Citation

Julia G. Levy, R. K. Chowdhary, Leslie G. Ratkay, Douglas Waterfield, Modestus Obochi, Simon Leong, David W. C. Hunt, and Agnes H. Chan "Immune modulation using transdermal photodynamic therapy", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199139

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available