Fluorescence detection system using a krypton laser: application to cancer diagnosis in photodynamic therapy

Marie-Luce Diller; Yves Granjon; Francois H. Guillemin; Edouard Yvroud

doi:10.1117/12.199153

12 January 1995 Fluorescence detection system using a krypton laser: application to cancer diagnosis in photodynamic therapy

Marie-Luce Diller, Yves Granjon, Francois H. Guillemin, Edouard Yvroud

Author Affiliations +

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199153
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

The hematoporphyrin derivative (HpD) is one of the most employed fluorescent markers for cancer diagnosis due to its ability to localize itself at a higher level in most tumor tissues and to emit a characteristic red fluorescence upon excitation with light at proper wavelength. This autofluorescence is responsible for a significant decrease of the fluorescence contrast between the tumor and the surrounding normal tissue. Consequently, there is a need to develop techniques to detect this fluorescence. This paper deals with the conception of a diagnosis system to detect early cancer at the surface of the hollow organs in the human body by endoscopy. The device and the principle of the image processing are detailed, and the limits of this system are discussed through the analysis of measurements carried out on phantoms and nude mice.

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Marie-Luce Diller, Yves Granjon, Francois H. Guillemin, and Edouard Yvroud "Fluorescence detection system using a krypton laser: application to cancer diagnosis in photodynamic therapy", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199153

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