Experimental research of the possible use of photodynamic methods in the treatment of melanoma of the iris

Tadeusz Kecik; Iwona Switka-Wieclawska; Jan Kasprzak; Alfreda Graczyk; Antoni Pratnicki

doi:10.1117/12.203328

1 March 1995 Experimental research of the possible use of photodynamic methods in the treatment of melanoma of the iris

Tadeusz Kecik, Iwona Switka-Wieclawska, Jan Kasprzak, Alfreda Graczyk, Antoni Pratnicki

Proceedings Volume 2203, Laser Technology IV: Applications in Medicine; (1995) https://doi.org/10.1117/12.203328
Event: Laser Technology: Fourth Symposium, 1993, Szczecin, Poland

Abstract

In our experimental work we present the use of hematoporphyrin derivative photodynamic therapy (HpD-PDT) in the treatment of melanoma. Eighteen eyes of rabbits were incubated intracamerally with amelanotic Greene melanoma tissue. The technique involves the administration of HpD and photoactivation of tumor with red light (630 nm) to achieve selective destruction of cancer cells. After photoradiation the tumor showed blanching and shrinkage, we could also observe the tumor vasculature damaged. Successfully treated tumors had large areas of necrosis with severely damaged blood vessels in histopathological examination. Results indicate that HpD-PDT is a very promising modern modality offering a new method of melanoma treatment.

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Tadeusz Kecik, Iwona Switka-Wieclawska, Jan Kasprzak, Alfreda Graczyk, and Antoni Pratnicki "Experimental research of the possible use of photodynamic methods in the treatment of melanoma of the iris", Proc. SPIE 2203, Laser Technology IV: Applications in Medicine, (1 March 1995); https://doi.org/10.1117/12.203328

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