New effects in photodynamic therapy of tumors

A. A. Akimov; A. S. Barchuk; M. L. Gel'fond; V. G. Maslow; N. B. Mihailova; Robert Petrovich Ogurtsov; T. P. Prokof'eva; Vladimir Victorovic Ryl'kov; I. E. Samsonova; Alexsander Nikolaevic Stukov; V. A. Filov

doi:10.1117/12.183139

10 August 1994 New effects in photodynamic therapy of tumors

A. A. Akimov, A. S. Barchuk, M. L. Gel'fond, V. G. Maslow, N. B. Mihailova, Robert Petrovich Ogurtsov, T. P. Prokof'eva, Vladimir Victorovic Ryl'kov, I. E. Samsonova, Alexsander Nikolaevic Stukov, V. A. Filov

Author Affiliations +

Proceedings Volume 2097, Laser Applications; (1994) https://doi.org/10.1117/12.183139
Event: Laser Optics, 1993, St. Petersburg, Russian Federation

Abstract

In this report there are the experimental results, which has been received with cell cultures and animals. We have found the photosensitized stimulation of the protective reactions of an organism, which has no direct connection with the photosensitization of the tumor cell destruction. It has been supposed that this photobiological process started from the photomodification of malignant cell membranes, its making strange cells for organism, and/or from the photomodification of the immunocompetent cells of the peripheral blood, increasing its cell killer activity. It has been shown that there are at least two competitive photoprocesses at use of monochromatic light. The first realizes the sensitized photodestruction of the malignant cells, and the second stimulates their reproduction. The latter decreases efficiency of PDT. It has found that the polychromatic (white) light suppressed processes of the malignant cell reproduction.

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A. A. Akimov, A. S. Barchuk, M. L. Gel'fond, V. G. Maslow, N. B. Mihailova, Robert Petrovich Ogurtsov, T. P. Prokof'eva, Vladimir Victorovic Ryl'kov, I. E. Samsonova, Alexsander Nikolaevic Stukov, and V. A. Filov "New effects in photodynamic therapy of tumors", Proc. SPIE 2097, Laser Applications, (10 August 1994); https://doi.org/10.1117/12.183139

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