Time-resolved fluorescence spectroscopy of tetrasulfonated aluminum phthalocyanine in solution and cells

L. V. Zhorina; Andrey Yuri Chikishev; Maria G. Galpern; Marina Yu. Poroshina; Elena B. Chernyaeva

doi:10.1117/12.168690

1 March 1994 Time-resolved fluorescence spectroscopy of tetrasulfonated aluminum phthalocyanine in solution and cells

L. V. Zhorina, Andrey Yuri Chikishev, Maria G. Galpern, Marina Yu. Poroshina, Elena B. Chernyaeva

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168690
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Tetrasulphonated aluminum phthalocyanine (AlPcS₄) is one of the extensively studied second generation sensitizers for photodynamic therapy of cancer. We've applied picosecond fluorescence spectroscopy to study the fluorescence decay lifetimes of AlPcS₄ in phosphate buffer at different pH values and in monolayers of cultured cells incubated in photosensitizer solution. The decay time for the cells in the buffer is closer to the one obtained for acidic aqueous solution indicating that at least part of the phthalocyanine could be found in the acidic microenvironment (lysosomes, etc.).

Citation Download Citation

L. V. Zhorina, Andrey Yuri Chikishev, Maria G. Galpern, Marina Yu. Poroshina, and Elena B. Chernyaeva "Time-resolved fluorescence spectroscopy of tetrasulfonated aluminum phthalocyanine in solution and cells", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168690

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