Synthesis and biological evaluation of a series of new germanium phthalocyanines incorporated into liposomes--part II: biological evaluation

Klaus Schieweck; Hans-Georg Capraro; Ute Isele; Ernst Batt; Martin Ochsner; Peter van Hoogevest; William G. Love

doi:10.1117/12.168649

1 March 1994 Synthesis and biological evaluation of a series of new germanium phthalocyanines incorporated into liposomes--part II: biological evaluation

Klaus Schieweck, Hans-Georg Capraro, Ute Isele, Ernst Batt, Martin Ochsner, Peter van Hoogevest, William G. Love

Author Affiliations +

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168649
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

The pharmacokinetic and phototherapeutic properties of new phthalocyanines with Ge(IV) or Si(VI) as the central metal ion and cholesterol, cholestan or long-chain fatty acids residues as axial ligands to the central ion have been studied in tumor-bearing mice. The new photosensitizers were selectively taken up by and relatively quickly released from the tumors. Except for Si(IV)-Pc, which showed a comparably high selectivity for tumor versus peritumoral tissue, all Ge(IV)-Pc were less selective than liposomal Zn-Pc (CGP 55847). However, all the new compounds showed excellent phototherapeutic efficiency at very low drug and light doses in studies in Meth-A-sarcoma-bearing mice.

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Klaus Schieweck, Hans-Georg Capraro, Ute Isele, Ernst Batt, Martin Ochsner, Peter van Hoogevest, and William G. Love "Synthesis and biological evaluation of a series of new germanium phthalocyanines incorporated into liposomes--part II: biological evaluation", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168649

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