Imaging of biological tissues by means of a time-gated confocal scanning: experimental and numerical results

Giovanni Zaccanti; Piero Bruscaglioni; F. Martinelli; Massimo Gurioli; Renzo Salimbeni; Marco Ferrari

doi:10.1117/12.154675

14 September 1993 Imaging of biological tissues by means of a time-gated confocal scanning: experimental and numerical results

Giovanni Zaccanti, Piero Bruscaglioni, F. Martinelli, Massimo Gurioli, Renzo Salimbeni, Marco Ferrari

Author Affiliations +

Proceedings Volume 1888, Photon Migration and Imaging in Random Media and Tissues; (1993) https://doi.org/10.1117/12.154675
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Numerical and experimental results of a study carried out to investigate the capabilities of the time gating technique to enhance images of biological tissues are reported. In particular we have investigated the confocal scanning configuration. The experimental results were obtained by using a picosecond laser and a streak camera system. The numerical results were obtained by using Monte Carlo simulations. Both elementary and semianalytic Monte Carlo methods were used. The numerical results showed that by using the time gating technique the contrast can be significantly increased when a short gating time is used. The measured time resolved spread functions were in general good agreement with numerical results. However, the experimental results showed that with our experimental setup it is difficult to measure with sufficient accuracy the small energy received during a short gating time when the slab of tissue is larger than 1 cm.

Citation Download Citation

Giovanni Zaccanti, Piero Bruscaglioni, F. Martinelli, Massimo Gurioli, Renzo Salimbeni, and Marco Ferrari "Imaging of biological tissues by means of a time-gated confocal scanning: experimental and numerical results", Proc. SPIE 1888, Photon Migration and Imaging in Random Media and Tissues, (14 September 1993); https://doi.org/10.1117/12.154675

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