Porphyrins as radiosensitizers in 60Co-irradiated E. ascites tumor cells: possibility to combine with PDT

Zivile Luksiene; B. Juodka

doi:10.1117/12.146296

18 June 1993 Porphyrins as radiosensitizers in 60Co-irradiated E. ascites tumor cells: possibility to combine with PDT

Zivile Luksiene, B. Juodka

Proceedings Volume 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II; (1993) https://doi.org/10.1117/12.146296
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Efficiency of Ehrlich ascites cells radiosensitization by porphyrins is a function of irradiation dose. The maximal radiosensitization was reached at the dose--2Gy. Moreover, efficiency of cell radiosensitization depends on extracellular porphyrins concentration Hematoporphyrin (HP) and hemaporphyrin dimethylether (HPde) have different radiosensitizing effect on cells. One of the reasons of such phenomenon may be the different degree of hydrofobicity of those porphyrins. The studies of intracellular porphyrins concentration show that they differ in the case of HP and HPde in the same order as cell radiosensitization efficiencies.

Citation Download Citation

Zivile Luksiene and B. Juodka "Porphyrins as radiosensitizers in 60Co-irradiated E. ascites tumor cells: possibility to combine with PDT", Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); https://doi.org/10.1117/12.146296

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