Observations of the incidence of metastasis following laser hyperthermia in combination with chemotherapy, PDT, and excision

Mianjing Wang; Menglin Gao; Jin Gao; Kexun Xue; Zuyan Xu; Jingyuan Zhang; Qongru Li; Zifan Geng; Zhuo Gong; Qing Ye; Pei Gu; Jing-Lian Xao

doi:10.1117/12.136997

5 March 1993 Observations of the incidence of metastasis following laser hyperthermia in combination with chemotherapy, PDT, and excision

Mianjing Wang, Menglin Gao, Jin Gao, Kexun Xue, Zuyan Xu, Jingyuan Zhang, Qongru Li, Zifan Geng, Zhuo Gong, Qing Ye, Pei Gu, Jing-Lian Xao

Author Affiliations +

Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.136997
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China

Abstract

Our early observations have confirmed that laser hyperthermia or PDT alone does not promote the tumor metastasis. In order to evaluate the combined effect of local tumor laser hyperthermia on the distant metastasis, transplantable forestomach carcinoma (Fc) in 615 line mice was treated by Nd:YAG laser hyperthermia (45 degree(s)C/20 min) combined with PDT (HpD 5 mg/kg, 480 J/cm², 20 min), chemotherapy (Cyclophosphamide 28.8 mg/kg) and excision, respectively. The results show that (1) the tumor growth inhibition by various treatment was significant compared with a control group; (2) no statistics different in metastasis rate were observed in laser hyperthermia combined with PDT, chemotherapy, or scalpel excision separately. It is suggested that laser hyperthermia combined with PDT, chemotherapy, or excision does not increase the incidence of the tumor metastasis.

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Mianjing Wang, Menglin Gao, Jin Gao, Kexun Xue, Zuyan Xu, Jingyuan Zhang, Qongru Li, Zifan Geng, Zhuo Gong, Qing Ye, Pei Gu, and Jing-Lian Xao "Observations of the incidence of metastasis following laser hyperthermia in combination with chemotherapy, PDT, and excision", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.136997

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