Hematoporphyrin-derivative photodynamic in-vitro sensitivity testing for brain tumors

Michael Plattner; Walter Bernwick; Herwig Kostron

doi:10.1117/12.136967

5 March 1993 Hematoporphyrin-derivative photodynamic in-vitro sensitivity testing for brain tumors

Michael Plattner, Walter Bernwick, Herwig Kostron

Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.136967
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China

Abstract

Brain tumors of various histologies were subjected to an in-vitro photodynamic-sensitivity test. The studies were performed on primary cultures of human glioblastomas, meningiomas, and ependymomas, which were exposed to increasing concentrations of hematoporphyrin derivative and 60 J/cm² delivered by an argon-dye laser at 632 nm. A growth inhibition of 75% was demonstrated at a concentration of 25 (mu) g and 10 (mu) g HPD/ml medium for two different glioblastomas, respectively. A growth inhibition of 75% was observed in the ependymoma line at 10 and 50 (mu) g HPD/ml with and without light, respectively. The meningioma demonstrated a 75% inhibition already at (mu) g and 75 (mu) g/ml medium with and without light, respectively. These results demonstrate a significant difference in the response of brain tumors to photodynamic treatment (PDT). In vitro-PDT-assay should be taken into account if clinical application of PDT is considered.

Citation Download Citation

Michael Plattner, Walter Bernwick, and Herwig Kostron "Hematoporphyrin-derivative photodynamic in-vitro sensitivity testing for brain tumors", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.136967

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