Laser-induced shock wave effects on red blood cells

Thomas J. Flotte M.D.; Joan K. Frisoli; Margaret Goetschkes; Apostolos George Doukas

doi:10.1117/12.44087

1 June 1991 Laser-induced shock wave effects on red blood cells

Thomas J. Flotte M.D., Joan K. Frisoli, Margaret Goetschkes, Apostolos George Doukas

Proceedings Volume 1427, Laser-Tissue Interaction II; (1991) https://doi.org/10.1117/12.44087
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

The trend for laser-based medical therapies has been towards short- pulse, high-peak power lasers. A consequence of using these lasers is the production of pressure waves that may propagate deep into tissue. Our previous experiments have concentrated on describing these effects and examining methods for measuring laser-induced shock waves. These two approaches were combined to study the effects of well-defined shock waves on red blood cells in vitro. Red blood cells were exposed to shock waves in capillary tubes covered with either latex or polyimide. The latex was deformed by the expanding plasma bubble whereas the polyimide was not. In the latex experiments where the cells were exposed to the bubble expansion in addition to the shock waves, damage to the cells was much greater. When the cells were exposed only to the shock waves through the polyimide, much less damage was apparent. This is the first clear example of the separation of different mechanical effects on tissue damage. In addition, the shock wave damage is not as significant as the damage caused by the bubble expansion.

Citation Download Citation

Thomas J. Flotte M.D., Joan K. Frisoli, Margaret Goetschkes, and Apostolos George Doukas "Laser-induced shock wave effects on red blood cells", Proc. SPIE 1427, Laser-Tissue Interaction II, (1 June 1991); https://doi.org/10.1117/12.44087

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available