Photodynamic therapy for early malignancies in the lower female genital tract

Rocco V. Lobraico

doi:10.1117/12.23762

1 September 1990 Photodynamic therapy for early malignancies in the lower female genital tract

Rocco V. Lobraico

Proceedings Volume 1353, First International Conference on Lasers and Medicine; (1990) https://doi.org/10.1117/12.23762
Event: First International Conference on Lasers and Medicine, 1990, Tashkent, Uzbekistan

Abstract

A total of 14 patients who had failed all conventional modalities for cancer of the vulva vagina and perianal area were treated with photodynamic therapy PDT. The affinity of porphyrins to neopJ. astic tissue enables treatment to be concentrated at the tumor site. An Aurora FL Argon pumped dye laser (Cooper LaserSonics Inc. USA) was used to pump dicyanomethylene dye as an activating source for a red light at a wavelength of 630 nm. The combination of a tumor localizing photosensitizer and photoactivating red light produces a photo chemical reaction that is destructive to the cancerous lesion. The treatment time varied between 10-30 minutes. Vulvar sites ranged from 9-38 cm2. Delivered light doses were from 50-125 J/cm2 and power density from 50 to 75 mW/cm2. A complete response was obtained in 80 of the sites treated as evidenced by negative biopsies taken at 3 months post treatment. Adverse reactions to PDT included a transient cutaneous photosensitivity due to retention of the photosensitizers in the skin. This reaction usually persisted from 45-60 days. 1.

Citation Download Citation

Rocco V. Lobraico "Photodynamic therapy for early malignancies in the lower female genital tract", Proc. SPIE 1353, First International Conference on Lasers and Medicine, (1 September 1990); https://doi.org/10.1117/12.23762

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