Biophysical modeling of rod photoreceptors based on phototransduction and ionic channel

Chunyan Liu; Fangfang Ning; Qing Liu; Jiali Ren; Meiyu Jiang; Yongqi Zhang; Yang Lei; Qun Niu; Qing-an Ding; Binghui Hou; Xiaoyuan Li

doi:10.1117/12.3044725

5 December 2024 Biophysical modeling of rod photoreceptors based on phototransduction and ionic channel

Chunyan Liu, Fangfang Ning, Qing Liu, Jiali Ren, Meiyu Jiang, Yongqi Zhang, Yang Lei, Qun Niu, Qing-an Ding, Binghui Hou, Xiaoyuan Li

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Proceedings Volume 13418, Fifteenth International Conference on Information Optics and Photonics (CIOP 2024); 134180G (2024) https://doi.org/10.1117/12.3044725
Event: 15th International Conference on Information Optics and Photonics (CIOP2024), 2024, Xi’an, China

Abstract

Photons are captured by rhodopsin in rod outer segments, where they are converted into an electrical signal. Modeling the light-sensitive electrical behavior of rods can reveal their biophysical mechanisms. However, most rod cell models are empirically based and lack biophysical meanings. In this paper, a model for rod cells based on the protein cascade transduction process and ion channels is presented. Based on the biochemical cascade of phototransduction in the rod outer segment, the model describes the formation of photocurrent and simulates the photocurrent response to different light stimuli. In addition, the model analyses the contribution of ion channels to light-response processes in photoreceptors and determines the relationship between light intensity and photovoltage response amplitude. This study presents an effective strategy for probing the internal phototransduction mechanism of rod cells. Furthermore, the model also provides an objective and quantitative description method for monitoring retinal diseases.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Chunyan Liu, Fangfang Ning, Qing Liu, Jiali Ren, Meiyu Jiang, Yongqi Zhang, Yang Lei, Qun Niu, Qing-an Ding, Binghui Hou, and Xiaoyuan Li "Biophysical modeling of rod photoreceptors based on phototransduction and ionic channel", Proc. SPIE 13418, Fifteenth International Conference on Information Optics and Photonics (CIOP 2024), 134180G (5 December 2024); https://doi.org/10.1117/12.3044725

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KEYWORDS

Rods

Photocurrent

Ion channels

Data modeling

Rhodium

Calcium

Mathematical modeling

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