Exploring the potential mechanisms of Galla chinensis in anti-breast cancer using HS-SPME-GC-MS and bioinformatics

Bin Huang; Heng Jiang; Yanhua Tang; Wentao Chen; Ting Chen

doi:10.1117/12.3044112

27 August 2024 Exploring the potential mechanisms of Galla chinensis in anti-breast cancer using HS-SPME-GC-MS and bioinformatics

Bin Huang, Heng Jiang, Yanhua Tang, Wentao Chen, Ting Chen

Author Affiliations +

Proceedings Volume 13252, Fourth International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2024); 1325215 (2024) https://doi.org/10.1117/12.3044112
Event: 2024 Fourth International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2024), 2024, Kaifeng, China

Abstract

Volatile components in Galla chinensis have the potential to exhibit anti-breast cancer (BC) properties, but as of now, no studies are reporting the specific mechanisms of action. In this study, volatile components and their relative contents in G. chinensis were identified using HS-SPME-GC-MS technology, and the potential mechanisms of the anti-BC properties of these volatile components in G. chinensis were explored using bioinformatics methods. Through analysis, 28 compounds were identified, from which 10 candidate compounds were selected. A search and prediction yielded 160 drug-related targets and 18,061 disease-related targets. Using bioinformatics methods, 2 hub genes (MAOA and MAOB) closely related to BC were identified. Through GO and KEGG analysis, enrichment was obtained for 264 biological processes, 124 molecular functions, 61 cellular components, and 104 important pathways closely related to BC. The study results indicate that volatile components in G. chinensis may target MAOA and MAOB through compounds such as Naphthalene, decahydro-4a-methyl-1-methylene-7-(1-methylethenyl)-, [4aR-(4aà,7à,8aá)]-, and Benzoic acid, 2-ethylhexyl ester, inhibiting signal transduction in drug metabolism pathways such as Drug metabolism- cytochrome P450 and Tyrosine metabolism. The expression validation of hub genes further demonstrates significant differential expression of MAOA and MAOB genes between normal individuals and cancer patients. This study preliminarily explored the potential mechanism of the volatile components of G. chinensis in anti-BC. The findings not only provide new insights and methods for the treatment of BC but also offer new revelations and possibilities for the entire field of cancer research.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Bin Huang, Heng Jiang, Yanhua Tang, Wentao Chen, and Ting Chen "Exploring the potential mechanisms of Galla chinensis in anti-breast cancer using HS-SPME-GC-MS and bioinformatics", Proc. SPIE 13252, Fourth International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2024), 1325215 (27 August 2024); https://doi.org/10.1117/12.3044112

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