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4 October 2024 Micro and Nano 3D investigation of complex gut alterations-dementia interplay
Alessia Cedola, Francesca Palermo, Inna Bukreeva, Peter Cloetens, Timm Weitkamp, Claudia Balducci
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Proceedings Volume 13152, Developments in X-Ray Tomography XV; 1315206 (2024) https://doi.org/10.1117/12.3027250
Event: Optical Engineering + Applications, 2024, San Diego, California, United States
Abstract
Alzheimer's disease (AD) remains one of the foremost public health challenges of our time. Recently, attention has turned to the gut-brain axis, a complex network of communication between the gastrointestinal tract and the brain, as a potential player in the pathogenesis of AD. Here we exploited x-ray Phase Contrast Tomography to provide an in-depth analysis of the link between the gut condition and AD, exploring gut anatomy and structure in murine models. We conducted a comprehensive analysis by comparing the outcomes in various mouse models of cognitive impairment, including AD, frail mice, and frontotemporal dementia affected mice. We discovered an association between substantial changes in the gut structure and the presence of amyloid-beta (Aβ) in the brain. We found that the most important gut alterations are related to Aβ occurrence in the brain. In particular, we investigated the gut morphology, the distribution of enteric micro-processes and neurons in the ileum.
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Alessia Cedola, Francesca Palermo, Inna Bukreeva, Peter Cloetens, Timm Weitkamp, and Claudia Balducci "Micro and Nano 3D investigation of complex gut alterations-dementia interplay", Proc. SPIE 13152, Developments in X-Ray Tomography XV, 1315206 (4 October 2024); https://doi.org/10.1117/12.3027250
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KEYWORDS
Dementia
Alzheimer disease
Brain
Mouse models
Neurons
Pathogens
Phase contrast
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