Terahertz demethylation for cancer therapy

Joo-Hiuk Son

doi:10.1117/12.3028792

1 October 2024 Terahertz demethylation for cancer therapy

Joo-Hiuk Son

Author Affiliations +

Proceedings Volume 13141, Terahertz Emitters, Receivers, and Applications XV; 131410A (2024) https://doi.org/10.1117/12.3028792
Event: Optical Engineering + Applications, 2024, San Diego, California, United States

Abstract

Carcinogenesis involves DNA methylation which is a primary alteration in DNA in the development of cancer before genetic mutation. Because the abnormal DNA methylation is found in most cancer cells, the assessment of DNA methylation using terahertz radiation can be a novel optical method to detect and control cancer. The methylation has been directly observed by terahertz time-domain spectroscopy and this epigenetic chemical change could be manipulated to the state of demethylation using resonant terahertz radiation. Demethylation of cancer cells is a key issue in epigenetic cancer therapy and our results demonstrate the feasibility of the cancer treatment using optical technique.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Joo-Hiuk Son "Terahertz demethylation for cancer therapy", Proc. SPIE 13141, Terahertz Emitters, Receivers, and Applications XV, 131410A (1 October 2024); https://doi.org/10.1117/12.3028792

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