SERS-based biosensors for application in biomedicine

Anna Chiara De Luca

doi:10.1117/12.3027925

30 September 2024 SERS-based biosensors for application in biomedicine

Anna Chiara De Luca

Author Affiliations +

Proceedings Volume 13126, Molecular and Nanophotonic Machines, Devices, and Applications VII; 1312603 (2024) https://doi.org/10.1117/12.3027925
Event: Organic Photonics + Electronics, 2024, San Diego, California, United States

Abstract

This work underscores the advancements in Surface-enhanced Raman scattering (SERS) technology, particularly in biomedicine. Known for its high sensitivity and resolution, SERS is a powerful tool for detecting low-concentration analytes. The study focuses on SERS-based nanosensors applied to imaging, biochemical monitoring, diagnostics, and therapy. By combining Raman spectroscopy with SERS, the research achieves precise HER2 quantification in breast cancer cells at the single-cell level, offering insights into cancer heterogeneity and supporting personalized treatments. Additionally, SERS is used to monitor Galunisertib delivery within living colorectal cancer cells, using diatomite-based nanovectors with gold nanoparticles and a pH-sensitive gelatin coating. This setup allows for controlled drug release in response to the tumor microenvironment, with real-time, label-free quantification of Galunisertib at very low concentrations. These findings highlight the potential of SERS to improve the precision and effectiveness of drug delivery and cancer treatment strategies.

Conference Presentation

Citation Download Citation

Anna Chiara De Luca "SERS-based biosensors for application in biomedicine", Proc. SPIE 13126, Molecular and Nanophotonic Machines, Devices, and Applications VII, 1312603 (30 September 2024); https://doi.org/10.1117/12.3027925

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