Advancing cellular analyses through a fully automated imaging-based liquid handling platform

Meryem B. Avci; Sevim D. Yasar; Arif E. Cetin

doi:10.1117/12.3022957

18 June 2024 Advancing cellular analyses through a fully automated imaging-based liquid handling platform

Meryem B. Avci, Sevim D. Yasar, Arif E. Cetin

Proceedings Volume 12998, Optics, Photonics, and Digital Technologies for Imaging Applications VIII; 1299803 (2024) https://doi.org/10.1117/12.3022957
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Our talk introduces a fully automated imaging-based liquid processing platform to revolutionize traditional pipetting in cell culture studies. This system minimizes operational errors by automating processes, significantly enhancing efficiency. With expedited liquid handling and cell imaging capabilities, it maps cellular information. The platform comprises key modules, including Motion, Pipetting, Imaging, and Software, providing precise XYZ axis movement, fluid transfer, cell imaging, and algorithm-driven post-processing and hardware control. Utilizing a CNC-based Motion Module, the platform navigates well-plates precisely based on g-coding. The Imaging Module displays cells, while the Pipetting Module ensures efficient solution handling. System software, coordinating processes, capturing and processes data, guides investigations into cellular pathways and therapeutic profiling. The platform incorporates an incubator with customizable settings, maintaining optimal conditions for cellular analyses. This comprehensive system signifies a significant leap in laboratory technology, promising heightened precision, efficiency, and adaptability for advancing cellular research.

Conference Presentation

Citation Download Citation

Meryem B. Avci, Sevim D. Yasar, and Arif E. Cetin "Advancing cellular analyses through a fully automated imaging-based liquid handling platform", Proc. SPIE 12998, Optics, Photonics, and Digital Technologies for Imaging Applications VIII, 1299803 (18 June 2024); https://doi.org/10.1117/12.3022957

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KEYWORDS

Liquids

Imaging systems

Biological research

Cultural studies

Drug development

Humidity

Image processing

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