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Chronic wounds pose a substantial global health challenge, further complicated by the presence of biofilms, which are pathogenic bacterial colonies protected by a biopolymer matrix. These biofilms are notably resistant to both traditional antibiotics and host immune responses, underscoring the critical demand for innovative therapeutic strategies. Among such advancements, transdermal drug delivery mechanisms, particularly microneedle patches, have shown promise in addressing biofilm-related infections effectively. This research introduces a drug delivery system incorporating a piezoelectric transducer (PZT) with a strategically arranged array of drug-infused microneedles. The activation of this system through voltage application to the transducer generates ultrasound waves, facilitating the targeted dispersion of drugs through the creation of localized acoustic fields and fluid streaming. This study delves into the optimization of ultrasound parameters and the mechanics of acoustically assisted drug distribution, identifying the conditions under which ultrasound waves can enhance the transfer of therapeutic agents via microneedles. It distinguishes between resonant and non-resonant frequencies, which influence the pattern and efficiency of drug diffusion into biofilms. The analysis extends to the simulation of drug penetration into biofilms, offering insights into concentration profiles at various depths. This investigation not only highlights the potential of ultrasound-enhanced drug delivery for precision medicine but also suggests its applicability in treating a wide array of medical conditions. The ability to precisely control drug delivery, coupled with real-time monitoring, signifies a transformative approach to medical treatment, with the potential to significantly improve patient outcomes and quality of life.
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