A fiber-optic probe-based Raman imaging approach in combination with AR/MR visualization

Wei Yang; Qian Liu; Iwan W. Schie

doi:10.1117/12.2688868

6 November 2023 A fiber-optic probe-based Raman imaging approach in combination with AR/MR visualization

Wei Yang, Qian Liu, Iwan W. Schie

Proceedings Volume 12921, Third International Computing Imaging Conference (CITA 2023); 129211Y (2023) https://doi.org/10.1117/12.2688868
Event: Third International Computing Imaging Conference (CITA 2023), 2023, Sydney, Australia

Abstract

In this paper, we summarize our previous relevant works and demonstrate various approaches to overcome the common drawbacks of applying Raman probes for many applications. A handheld fiber-optic Raman probe with an autofocus unit was presented to overcome the problem arising from using fixed-focus lenses, by using a liquid lens as the objective lens, which allows dynamical adjustment of the focal length of the probe. An implementation of a computer vision-based positional tracking to co-register the regular Raman spectroscopic measurements with the spatial location enables fast recording of a Raman image from a large tissue sample by combining positional tracking of the laser spot through brightfield images. The visualization of the Raman image has been extended to augmented and mixed reality and combined with a 3D reconstruction method and projector-based visualization to offer an intuitive and easily understandable way of presenting the Raman image. All these advances are substantial and highly beneficial to further drive the clinical translation of Raman spectroscopy as potential image-guided instrumentation.

Citation Download Citation

Wei Yang, Qian Liu, and Iwan W. Schie "A fiber-optic probe-based Raman imaging approach in combination with AR/MR visualization", Proc. SPIE 12921, Third International Computing Imaging Conference (CITA 2023), 129211Y (6 November 2023); https://doi.org/10.1117/12.2688868

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