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13 March 2024 Mechanism study of photoacoustic neuromodulation
Guo Chen, Linli Shi, Feiyuan Yu, Ji-Xin Cheng, Chen Yang
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Proceedings Volume 12829, Optogenetics and Optical Manipulation 2024; 128290E (2024) https://doi.org/10.1117/12.3003090
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Neural circuitry and information transfer in the brain are poorly understood, necessitating new technologies for studying brain function and treating neurological disorders. Photoacoustic stimulation, using fiber-based optoacoustic emitters (FOE), allows precise neural stimulation. We investigated the role of the photothermal effect and found that pure photothermal neuromodulation requires significantly higher energy dosage compared to photoacoustic stimulation. Pharmacological inhibition revealed the importance of elastic modulus and ruled out a significant thermal effect from FOE. We also identified the involvement of Piezo1, TRPC1, and voltage-gated T-type calcium channels. These findings improve our understanding of photoacoustic neuromodulation and its potential clinical applications.
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Guo Chen, Linli Shi, Feiyuan Yu, Ji-Xin Cheng, and Chen Yang "Mechanism study of photoacoustic neuromodulation", Proc. SPIE 12829, Optogenetics and Optical Manipulation 2024, 128290E (13 March 2024); https://doi.org/10.1117/12.3003090
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KEYWORDS
Photoacoustic spectroscopy
Calcium
Action potentials
Brain
Continuous wave operation
Fiber lasers
Photothermal effect
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